Yes, choosing different detergents will affect the fabric of Pcing HME Queen Size Duvet Cover is a Blend Fabric, Duvet Cover is Equipped with a Hidden Zipper at the Bottom. Blended fabrics usually contain a mixture of natural fibers (such as cotton, linen, silk, wool, etc.) and synthetic fibers (such as polyester, nylon, etc.). The heat resistance of these fibers varies, and high-temperature ironing may cause the fabric to deform, shrink or be damaged. In particular, the natural fiber part is more sensitive to high temperatures and is easily damaged. Similarly, it is not recommended to wash blended fabrics at high temperatures. High-temperature washing may cause the fabric to shrink, deform or damage the fiber structure. Different fibers have different heat and water resistance. High temperatures and strong detergents may destroy the bonding between the fibers, resulting in a decrease in fabric quality.